My husband works in academia and generally just tries to avoid gender nonsense altogether. He is willing to play along to a certain extent when he has to, though, because jobs are... necessary. He has managed to keep pronouns out of his signature so far, and is the only one in his department without them, so he's already a little worried that's he outing himself.
He came to me this morning with a conundrum. He's like "you know, the whole pronoun thing isn't even helpful, practically." It turns out that he has to write a somewhat formal email to a colleague who he hasn't met or corresponded with yet (so he wouldn't feel comfortable using just the first name). This woman isn't a Dr. (so he can't use that out), and has the listed pronouns "they/them." He had no idea how to proceed and was a little stressed out about it. I joked that he should use "Mx. Soandso" and was met with a look of horror, so I suggested just using the whole name, which I figure is pretty safe and non-committal to ideology, if a little awkward sounding.
Does the general public know how to deal with that kind of situation? Fucking exhausting.