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I know about women needing 2/3rds the recommended dose of Aspirin, different heart attack symptoms, and generally lower blood pressure numbers. But I know I am missing a bunch. Is there a list anywhere?

I know about women needing 2/3rds the recommended dose of Aspirin, different heart attack symptoms, and generally lower blood pressure numbers. But I know I am missing a bunch. Is there a list anywhere?

8 comments

Here's a good article on the differences in some medications. https://www.aafp.org/afp/2009/1201/p1254.html

This is a good clinical explanation for some of the differences, if you understand drug metabolism. https://www.uspharmacist.com/article/gender-differences-in-pharmacokinetics

From that article (ignore their use of gender- they're using it interchangeably with sex - 2014)

Many CYP450 enzymes (phase I metabolism) show a sex-dependent difference in activity. Most of the phase II enzymes have a higher activity in men than in women.

CYP450 is the pathway (in the liver) that a lot of drugs are metabolized through to become active/get processed for removal from the body. Taking more than one drug at a time that goes through this pathway means they "compete" to be processed/removed and you can build up more than the typical dosage in your body. AND once in the CYP450 system, there are multiple pathways that each drug can take.

It's quite complicated, and they have found more and more of these enzyme pathways since I graduated pharmacy school almost 25yrs ago. On top of it being affected by sex, race/ethnicity (ie genetics) can also play a role in how efficient you metabolize some drugs vs others.

Wow. That is more scientific than I expected it to be. Guess I have my reading for the next week now. Thank you

Thank you. With all the crap about not disclosing sex to medical professionals this is useful.

Thank you SO MUCH for these links. Also I notice right away they are playing mix and match with "gender" and "sex," the way my generation always did. Not this new "WokeSpeak" way.

and gender-specific analysis is uncommon. Sex differences in metabolism

Follow-up question. When they say "Hispanic," they do not mean the culture, they mean specifically Mexican, Central American, and South American Indians (or "Indigenous, Pre-Columbian" I'm not sure what the "acceptable" term is now) don't they?

Two of my best friends are Mexican, one from Mexico, one born here. They are not the same race. Some Mexican people are Black. Others are blue-eyed. Many are 90% or more American Indian, or I guess "Native American" is the term now, but "Mexican Indian" -- not having many if any European or African ancestors. "Hispanic" usually refers to the culture. Here in California, many forms have "white (non-Hispanic)" as a box to tick.

"Hispanic" isn't really a clearly defined word because culture and race are not the same thing. To me, it's like "Islamic" or even "Western" -- tens of millions of Black people are Westerners, yet some people use "Western" to mean white.

Most people from India are Caucasian: defined largely by a high nose bridge. My best friend is Mexican and the doctor made a comment about her being Caucasian. Caucasian doesn't mean white. Nor does "Anglo" mean white (very misused in California!) In anthropology, you're talking about skull types, not skin color (which is long gone.)

Mexicans who are both Caucasian and Hispanic, might be very confused by this:

CYP2B6 expression and activity are higher in women than in men. Its activity also varies among different ethnic groups. In a previous study, CYP2B6 activity is lower in Hispanic men than in Caucasian or African-American men. In contrast, Hispanic women showed higher CYP2B6 activity when compared to Caucasian or African-American women. Therefore, drugs that are primarily metabolized by CYP2B6 may be less effective in women (especially Hispanic women) than in men.

They're using it as an ethnicity, not a race.

It's about genetics, and your parents and their parents... who would also look like you (light skinned, dark skinned, etc), so in this instance, I'd say they mean people who descend from people who are of Spanish descent. That would be my guess.