20

I know about women needing 2/3rds the recommended dose of Aspirin, different heart attack symptoms, and generally lower blood pressure numbers. But I know I am missing a bunch. Is there a list anywhere?

I know about women needing 2/3rds the recommended dose of Aspirin, different heart attack symptoms, and generally lower blood pressure numbers. But I know I am missing a bunch. Is there a list anywhere?

8 comments

Here's a good article on the differences in some medications. https://www.aafp.org/afp/2009/1201/p1254.html

This is a good clinical explanation for some of the differences, if you understand drug metabolism. https://www.uspharmacist.com/article/gender-differences-in-pharmacokinetics

From that article (ignore their use of gender- they're using it interchangeably with sex - 2014)

Many CYP450 enzymes (phase I metabolism) show a sex-dependent difference in activity. Most of the phase II enzymes have a higher activity in men than in women.

CYP450 is the pathway (in the liver) that a lot of drugs are metabolized through to become active/get processed for removal from the body. Taking more than one drug at a time that goes through this pathway means they "compete" to be processed/removed and you can build up more than the typical dosage in your body. AND once in the CYP450 system, there are multiple pathways that each drug can take.

It's quite complicated, and they have found more and more of these enzyme pathways since I graduated pharmacy school almost 25yrs ago. On top of it being affected by sex, race/ethnicity (ie genetics) can also play a role in how efficient you metabolize some drugs vs others.

Wow. That is more scientific than I expected it to be. Guess I have my reading for the next week now. Thank you